Clinic Trials

Novatrials Conducts Ethically Approved Clinical Trials

All new medical treatments are required to go through the clinical trial process to ensure they are effective and safe. This process can take several years before a medication is approved for wider use. Through clinical trials being offered here in Newcastle, the people of our region have the opportunity to access treatment, not otherwise available.
Each trial is run by a team of health professionals with a Specialist or GP overseeing each trial. Working alongside our Investigators is a highly qualified Nurse Practitioner. Registered Nurses are here to look after you during each visit and throughout the trial. You are well cared for every step of the way and there are no costs to participate.

Osteoarthritis of the Knee

Chronic knee pain holding you back?
If you suffer from chronic pain or aching in your knee, you may have osteoarthritis (OA) - a painful joint condition that can interfere with all aspects of daily life. If you are living with chronic knee pain and have not received lasting relief from medications, you may qualify for a new clinical research study. The study is for an investigational medication for chronic knee pain.

If you qualify and choose to join the study, you will receive study-related care at no cost and will also be reimbursed for your travel to attend study visits.
Osteoarthritis of the Knee
Currently Enrolling

Hidradenitis Suppurativa

Hidradenitis Suppurativa (HS) is a chronic inflammatory skin disorder causing painful lumps/nodules to form in areas where the skin rubs together such as armpits and groin. Novatrials is now running a trial of a potential new medication for HS.
If you are suffering with HS you may be eligible to join the trail if you:
• are aged 18 and over;
• diagnosed with or have HS signs/symptoms;
• can attend study vists at Kotara
Participants receive study treatment from our dedicated medical team at no cost. Participants are also reimbursed for travel expenses for study visits.
Hidradenitis Suppurativa
Currently Enrolling

Omicron Covid-19 Vaccine

Help us find a vaccine for Omicron We are seeking volunteers to participate in a Phase 3 clinical trial of a potential Novavax Covid-19 vaccine booster aimed at the Omicron variant. If you are aged over 18 years and have already received Covid-19 vaccinations of the following:

*At least 3 doses of an mRNA Vaccine (Either Pfizer and/or Moderna) at least 3 months ago

We want to hear from you if you meet any of the above and can attend 6 appointments over 8 months at Novatrials clinic in Kotara. Participants receive a vaccination and study-related health care from a dedicated medical team at no cost. Participants also receive $90 per visit for travel expenses for attending appointments.
Osteoarthritis of the Knee
Enrolment Now Closed

Atopic Dermatitis

Suffering with Eczema (Atopic Dermatitis). You may be eligible to participate if you:
* are aged 18-65 years of age (inclusive)
* have been diagnosed with moderate to severe Eczema (Atopic Dermatitis)
* have not had adequate response to other Eczema treatments in the last 12 months.
Participants receive study medication and study-related care from our dedicated medical team at no cost. Participants also receive travel expenses for attending appointments.
Atopic Dermatitis
Enrolment Now Closed

Nail Psoriasis

Do you have nail psoriasis? If so, you may be interested in a medical research study of a new topical medication.Individuals who qualify must be:
• 18 – 80 years old
• Diagnosed with fingernail psoriasis for at least 3 months
• Diagnosed with or have a history of plaque psoriasis or psoriatic arthritis
The study is 32 weeks long with a 2 week follow-up. For 16 weeks, patients will treat one side with active medication and one side with placebo. For another 16 weeks, all patients will receive active medication to treat both sides, with the option to treat whole body. The study is being conducted at multiple clinical sites across Australia.
Nail Psoriasis
Enrolment Now Closed

Alopecia

Do you have Alopecia? Novatrials are seeking volunteers with Alopecia to join a clinical trial of a potential new treatment. You may be eligible for the trial if: 
* You are aged between 18-65 years
* Have at least 25% or greater hair loss
* You can attend appointments at our Kotara clinic (8 visits over 8 months)
Participants receive study medication and study-related care by a dedicated medical team at no cost. Participants also receive travel expenses for each clinic appointment.
Hair loss
Enrolment Now Closed

Kidney Disease caused by Type 2 Diabetes

Having high levels of a protein called albumin in your urine could be a a sign of kidney damage. We are running a trial of a potential new medication that may help improve your kidneys. (The same medication is also being trialed for blood glucose control with associated weight loss).
You may be eligible to join the trial if you:
* Are aged between 18-75 years of age (inclusive)
* Have Type 2 Diabetes
* Have Diabetic Kidney Disease 
(if you don't know if you have high albumin, contact us to have a simple blood test to check for Albuminuria)
The trial involves 6 visits to the Kotara clinic over 4 months.
Participants receive study medication and study-related care from our dedicated medical team at no cost. Participants also receive travel expenses.
osteoporosis
Enrolment Now Closed

Osteoporosis

We are seeking volunteers to help us with an observational study for people diagnosed with Osteoporosis and have recently started on either Prolia or Alendronate (began treatment within the last 4 weeks). Participation in this study will consist of 1 visit to the clinic and 2 phone visits over 2 years.
osteoporosis
Enrolment Now Closed

Chronic Plaque Psoriasis

We are seeking volunteers with mild to moderate Chronic Plaque Psoriasis to participate in a trial of a skin gel applied to the psoriasis plaque for 28 days. You may be eligible for the trial if you are:
* Aged 18-75 years
* Diagnosed with Chronic Plaque Psoriasis
* Otherwise healthy
There are 7 appointments at the clinic over 8 weeks. Study medication and study-related care from a dedicated medical team provided at no cost. You receive $80 per visit for travel expenses. One of the appointments requires you to spend 6 hours at the clinic, for which you are paid for your time.
Chronic Plaque Psoriasis
Enrolment Now Closed

Heart Failure

This trial is looking at a potential new treatment option for heart failure. You may be eligible to participate if you have been diagnosed with chronic heart failure and have not had a serious heart event (such as a heart attack, stroke, or major heart surgery) within the last 90 days.
Heart
Enrollment Now Closed

Hypercholesterolaemia with Statin Intolerance

This is a potential new treatment option for people with, or at high risk for, cardiovascular disease (heart disease) who are unable to tolerate statin medications.
Cholesterol
Enrollment Now Closed

Rosacea (Papulopustular)

Do you regularly have flushing or redness with an acne-like breakout on your forehead, cheeks, nose and surrounding area or chin?
Have you been diagnosed with Rosacea?
A research study is now underway for an investigational new treatment for Rosacea and you could be eligibil for this 8 week study.
Medication and check-ups are included and travel costs will be reimbursed.
Rosacea (Papulopustular)
Enrolment Now Closed

Frequently Asked Questions

  • What is a Clinical Trial?

    Clinical trials are an essential part of the development of new interventions and tests that may improve your health care, alleviate the symptoms of your disease or condition or improve the health care of others. Clinical trials are research investigations in which people volunteer to test new treatments, interventions or tests as a means to prevent, detect, treat or manage various diseases or medical conditions. Some investigations look at how people respond to a new intervention and what side effects might occur. This helps to determine if a new intervention works, if it is safe, and if it is better than the interventions that are already available.


    Clinical trials might also compare existing interventions, test new ways to use or combine existing interventions or observe how people respond to other factors that might affect their health (such as dietary changes).


    The World Health Organization (WHO) definition for a clinical trial is ‘any research study that prospectively assigns human participants or groups of humans to one or more health-related interventions to evaluate the effects on health outcomes’. Clinical trial interventions include but are not restricted to:


    • Experimental Drugs
    • Cells and Other Biological Products
    • Vaccines
    • Medical Devices
    • Surgical and Other Medical Treatments and Procedures
    • Psychotherapeutic and Behavioural Therapies
    • Health Service Changes
    • Preventive Care Strategies and
    • Educational Interventions
  • Why Participate In a Clinical Trial?
    • You may get a new treatment for a disease before it is available to everyone.
    • You play a more active role in your own health care.
    • Researchers may provide you with medical care and more frequent health check-ups as part of your treatment.
    • You may have the chance to help others get a better treatment for their health problems in the future.
    • You may be able to get information about support groups and resources.

    Clinical trials are essential to the development of new medical treatments and diagnostic tests. Without clinical trials, we cannot properly determine whether new treatments developed in the laboratory or by using animal models are effective or safe or whether a diagnostic test may work properly. This is because computer simulation and animal testing can only tell us so much about how a new treatment might work, and are no substitute for testing in a living human body.


    Clinical trials also allow testing and monitoring of the effect of a treatment on a large number of people to ensure that any improvement as a result of the treatment occurs for many people and is not just a random effect for one person. Most modern medical treatments are a direct result of clinical research. New treatments for all diseases and conditions — including cancer, heart disease, high blood pressure and asthma — have been developed through clinical research. Clinical trials often lead to new treatments that help people to live longer, and to have less pain or disability.


    For example, clinical trials can help:

    • prevent diseases by testing a vaccine
    • detect or diagnose diseases or conditions, for example by testing a blood sample
    • treat diseases or conditions by testing a new medicine or other medical procedure
    • find out how people can control their symptoms or improve their quality of life by testing how a particular diet affects a condition.

    Clinical trials also help to improve health care services by raising standards of treatment. Doctors and hospital staff involved in clinical trials are continually trained to provide best practice patient care. Australian clinical trials are recognised internationally as providing very high quality patient care.

  • What is Informed Consent?

    Anyone taking part in a trial must be fully informed about the objectives of the research, what is expected of them and any risks and potential inconveniences that may be experienced during and after the trial. If you are thinking of being part of a trial, you should be given a participant information and consent form that contains details of the trial and your participation as part of the process of informed consent.


    Trials must follow a carefully controlled protocol, which is a plan that describes what researchers will do in the study. As a clinical trial progresses, researchers may report the results of the trial at scientific meetings, to medical journals and to various government agencies. When they do this, the names and personal details of trial participants are kept confidential and are not disclosed.

  • Will I Be Paid To Participate In a Trial?

    Clinical trials are conducted, or ‘sponsored’, by a wide range of organisations. They include:

    • Pharmaceutical companies, either solely or jointly with other research institutions such as universities and hospitals;
    • Private research organisations under a grant from the government’s National Health & Medical Research Council or from public donations;
    • Publicly funded research organisations such as universities and teaching hospitals.

    Regardless of the type of organisation sponsoring the clinical trial, the clinical trial must be approved and monitored under the ethical and good clinical practice guidelines set down by the Australia government.


    Clinical trial participants may be reimbursed for travel and parking costs. Healthy volunteers participating in early stage testing may be paid for their time.

  • What is Ethics?

    Clinical trials in Australia are regulated by laws and codes of conduct that aim to protect trial participants and the integrity of the research. All clinical research projects in Australia must be approved by a Human Research Ethics Committee (HREC), which checks that the research conforms to the requirements of the National Statement on Ethical Conduct in Human Research.

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